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Amorphous calcium phosphate : ウィキペディア英語版 | Amorphous calcium phosphate Amorphous calcium phosphate (ACP or ATCP) is a glassy precipitate of variable composition that is formed in double decomposition reactions involving a soluble phosphate and calcium salts (e.g. (NH4)2HPO4 + Ca(NO3)2)〔 〕 performed under carefully controlled pH conditions. The precipitate will either be "amorphous tricalcium phosphate", ATCP, or calcium deficient hydroxypatite, CDHA, Ca9(HPO4)(PO4)5(OH), (note CDHA is sometimes termed apatitic calcium triphosphate).〔〔 〕〔 〕 The composition of amorphous calcium phosphate is CaxHy(PO4)z· nH2O where n is between 3 and 4.5.〔 ==Biogenic ACP== Biogenic ACP has been found in the inner ear of embryonic sharks, mammalian milk and dental enamel. However whilst the unequivocal presence of ACP in bones and teeth is the subject of debate, there is evidence that transient amorphous precursors are involved in the development of bone and teeth.〔 The ACP in bovine milk is believed to involve calcium phosphate nanoclusters covered in a shell of casein phosphopeptides. A typical casein micelle of radius 100 nm contains around 10,000 casein molecules and 800 nanoclusters of ACP each of an approximate diameter of 4.8 nm. The concentration of calcium phosphate is higher in milk than in serum but it rarely forms deposits of insoluble phosphates.〔 〕 Unfolded phosphopeptides are believed to sequester ACP nanoclusters, and form stable complexes in other biofluids such as urine and blood serum, thus preventing deposition of insoluble calcium phosphates and calcification of soft tissue. In the laboratory stored samples of formulations of artificial blood serum urine and milk that approximate the pH of the naturally occurring fluids deposit insoluble phosphates. The addition of suitable phosphopeptides prevents precipitation.〔
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